| Short Description : | Rabbit polyclonal anti-Serine protease inhibitor Kazal-type 5 (494-543 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPINK5 |
| Gene ID: | 11005 |
| Uniprot ID: | ISK5_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SPINK5 at the amino acid range 494-543 |
| Immunogen Region: | 494-543 aa |
| Specificity: | LEKTI Polyclonal Antibody detects endogenous levels of LEKTI protein. |
| Post Translational Modifications | Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases. |
| Function | Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. |
| Protein Name | Serine Protease Inhibitor Kazal-Type 5Lympho-Epithelial Kazal-Type-Related InhibitorLekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665 |
| Database Links | Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Serine Protease Inhibitor Kazal-Type 5 antibodyAnti-Lympho-Epithelial Kazal-Type-Related Inhibitor antibodyAnti-Lekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665 antibodyAnti-SPINK5 antibody |
Information sourced from Uniprot.org
