| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein Spindly (541-590 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SPDL1 |
| Gene ID: |
54908 |
| Uniprot ID: |
SPDLY_HUMAN |
| Immunogen Region: |
541-590 aa |
| Specificity: |
CCDC99 Polyclonal Antibody detects endogenous levels of CCDC99 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CCDC99 at the amino acid range 541-590 |
| Function | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Plays a role in cell migration. |
| Protein Name | Protein SpindlyHspindlyArsenite-Related Gene 1 ProteinCoiled-Coil Domain-Containing Protein 99Rhabdomyosarcoma Antigen Mu-Rms-40.4aSpindle Apparatus Coiled-Coil Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeCentromereKinetochoreNucleusSpindle PoleLocalizes To The Nucleus In Interphase And To The Kinetochore In Early PrometaphaseRelocalizes To The Mitotic Spindle Pole Before Metaphase And Is Subsequently Lost From The Spindle Poles After Chromosome Congression Is CompletedRemoval Of This Protein From The Kinetochore Requires The Dynein/Dynactin Complex |
| Alternative Antibody Names | Anti-Protein Spindly antibodyAnti-Hspindly antibodyAnti-Arsenite-Related Gene 1 Protein antibodyAnti-Coiled-Coil Domain-Containing Protein 99 antibodyAnti-Rhabdomyosarcoma Antigen Mu-Rms-40.4a antibodyAnti-Spindle Apparatus Coiled-Coil Domain-Containing Protein 1 antibodyAnti-SPDL1 antibodyAnti-CCDC99 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
