| Short Description : | Rabbit polyclonal anti-Spermatogenesis-associated protein 2 (119-169 aa) for use in WB, ELISA and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPATA2 |
| Gene ID: | 9825 |
| Uniprot ID: | SPAT2_HUMAN |
| Immunogen: | Synthesized peptide derived from the human SPAT2 at the amino acid range 119-169 |
| Immunogen Region: | 119-169 aa |
| Specificity: | This antibody detects endogenous levels of SPAT2 at Human |
| Function | Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD. |
| Protein Name | Spermatogenesis-Associated Protein 2 |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956 |
| Cellular Localisation | CytoplasmNucleusDetected In The Tubular Compartment Of The Testis AndIn The Cytoplasm Of The Sertoli Cells |
| Alternative Antibody Names | Anti-Spermatogenesis-Associated Protein 2 antibodyAnti-SPATA2 antibodyAnti-KIAA0757 antibodyAnti-PD1 antibody |
Information sourced from Uniprot.org
