Anti-SP7 antibody (280-360 aa) (STJ190436)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 280-360
General Information
| Short Description | Rabbit polyclonal anti-Transcription factor Sp7 (280-360 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SP7 |
| Gene ID | 121340 |
| Uniprot ID | SP7_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 280-360 |
| Immunogen Region | 280-360 aa |
| Specificity | SP7 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours. Propionylated. Depropionylation at Lys-371 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts. |
| Function | Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. |
| Protein Name | Transcription Factor Sp7Zinc Finger Protein Osterix |
| Database Links | Reactome: R-HSA-8940973 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Sp7 antibodyAnti-Zinc Finger Protein Osterix antibodyAnti-SP7 antibodyAnti-OSX antibody |
Information sourced from Uniprot.org