Anti-SOX2 antibody (10-70 aa) (STJ13102143)

SKU:
STJ13102143-150
$447.53
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: IHC/WB
Reactivity: Mouse/Rat/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SOX2 (10-70 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: Sox2
Gene ID: 20674
Uniprot ID: SOX2_MOUSE
Immunogen Region: 10-70 aa
Specificity: Specific for SOX2.
Immunogen: A synthetic peptide from aa region of 10-70 of mouse SOX2 conjugated to an immunogenic carrier protein was used as the antigen.
Post Translational Modifications Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. Methylation at Lys-44 and Lys-119 is necessary for the regulation of SOX2 proteasomal degradation. Ubiquitinated by WWP2, leading to proteasomal degradation.
Function Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.
Protein Name Transcription Factor Sox-2
Database Links Reactome: R-MMU-3769402
Cellular Localisation Nucleus
Cytoplasm
Nuclear Import Is Facilitated By Xpo4
A Protein That Usually Acts As A Nuclear Export Signal Receptor
Alternative Antibody Names Anti-Transcription Factor Sox-2 antibody
Anti-Sox2 antibody
Anti-Sox-2 antibody

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ13102204 Anti-SOX2 antibody (250-318 aa) (STJ13102204) Rabbit Polyclonal Mouse/Rat/Human IHC/WB
STJ13101278 Anti-KCNK1 antibody (10-70 aa) (STJ13101278) Rabbit Polyclonal Human/Rat/Mouse IHC/WB
STJ98555 Anti-SOX2 antibody (STJ98555) Mouse Monoclonal Human/Mouse/Rat/Cow/Pig/Sheep WB
STJA0016073 Anti-SOX2 antibody (1-68 aa) [R74-1A-2] (STJA0016073) Rabbit Monoclonal Human/Mouse WB/IHC-P/ICC/IF
STJ98396 Anti-SOX2 antibody [10F10] (STJ98396) Mouse Monoclonal Human WB/IHC/IF/ELISA
!