| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SOST |
| Gene ID: | 50964 |
| Uniprot ID: | SOST_HUMAN |
| Immunogen Region: | 24-213 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 24-213 of human SOST (NP_079513.1). |
| Immunogen Sequence: | QGWQAFKNDATEIIPELGEY PEPPPELENNKTMNRAENGG RPPHHPFETKDVSEYSCREL HFTRYVTDGPCRSAKPVTEL VCSGQCGPARLLPNAIGRGK WWRPSGPDFRCIPDRYRAQR VQLLCPGGEAPRARKVRLVA SCKCKRLTRFHNQSELKDFG TEAARPQKGRKPRPRARSAK ANQAELENAY |
| Tissue Specificity | Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). |
| Function | Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
| Protein Name | Sclerostin |
| Database Links | Reactome: R-HSA-201681 Reactome: R-HSA-3772470 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative Antibody Names | Anti-Sclerostin antibody Anti-SOST antibody Anti-UNQ2976 antibody Anti-PRO7455 antibody Anti-PRO7476 antibody |
Information sourced from Uniprot.org