• Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-SORD antibody (STJ194029)

SKU:
STJ194029

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sorbitol dehydrogenase-butanediol dehydrogenase is suitable for use in Western Blot and Immunoprecipitation research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IP 1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SORD
Gene ID: 6652
Uniprot ID: DHSO_HUMAN
Specificity: This antibody detects endogenous levels of DHSO at Human/Mouse/Rat
Immunogen: Synthesized peptide derived from the human DHSO
Function Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor.
Protein Name Sorbitol Dehydrogenase
Sdh
(R -R-Butanediol Dehydrogenase
L-Iditol 2-Dehydrogenase
Polyol Dehydrogenase
Ribitol Dehydrogenase
Rdh
Xylitol Dehydrogenase
Xdh
Database Links Reactome: R-HSA-5652227
Reactome: R-HSA-5661270
Cellular Localisation Mitochondrion Membrane
Peripheral Membrane Protein
Cell Projection
Cilium
Flagellum
Associated With Mitochondria Of The Midpiece And Near The Plasma Membrane In The Principal Piece Of The Flagellum
Also Found In The Epididymosome
Secreted By The Epididymal Epithelium And That Transfers Proteins From The Epididymal Fluid To The Sperm Surface
Alternative Antibody Names Anti-Sorbitol Dehydrogenase antibody
Anti-Sdh antibody
Anti-(R -R-Butanediol Dehydrogenase antibody
Anti-L-Iditol 2-Dehydrogenase antibody
Anti-Polyol Dehydrogenase antibody
Anti-Ribitol Dehydrogenase antibody
Anti-Rdh antibody
Anti-Xylitol Dehydrogenase antibody
Anti-Xdh antibody
Anti-SORD antibody

Information sourced from Uniprot.org

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