| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SORBS3 |
| Gene ID: |
10174 |
| Uniprot ID: |
VINEX_HUMAN |
| Immunogen Region: |
1-240 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SORBS3 (NP_005766.3). |
| Immunogen Sequence: |
MQGPPRSLRAGLSLDDFIPG HLQSHIGSSSRGTRVPVIRN GGSNTLNFQFHDPAPRTVCN GGYTPRRDASQHPDPAWYQT WPGPGSKPSASTKIPASQHT QNWSATWTKDSKRRDKRWVK YEGIGPVDESGMPIAPRSSV DRPRDWYRRMFQQIHRKMPD LQLDWTFEEPPRDPRHLGAQ QRPAHRPGPATSSSGRSWDH SEELPRSTFNYRPGAFSTVL QPSNQVLRRREKVDNVWTE |
| Tissue Specificity | Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver. |
| Post Translational Modifications | Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading. |
| Function | Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. |
| Protein Name | VinexinSh3-Containing Adapter Molecule 1Scam-1Sorbin And Sh3 Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Isoform Alpha: Cell JunctionCytoplasmCytoskeletonLocalized At Cell-Extracellular Matrix JunctionsBoth Isoforms Were Localized At Focal Adhesion And Cell-Cell Adhesion SitesIsoform Beta: Cell JunctionNucleusVinexin Beta Was Also Found In The Nucleus |
| Alternative Antibody Names | Anti-Vinexin antibodyAnti-Sh3-Containing Adapter Molecule 1 antibodyAnti-Scam-1 antibodyAnti-Sorbin And Sh3 Domain-Containing Protein 3 antibodyAnti-SORBS3 antibodyAnti-SCAM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
