| Tissue Specificity | Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver. |
| Post Translational Modifications | Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading. |
| Function | Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. |
| Protein Name | VinexinSh3-Containing Adapter Molecule 1Scam-1Sorbin And Sh3 Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Isoform Alpha: Cell JunctionCytoplasmCytoskeletonLocalized At Cell-Extracellular Matrix JunctionsBoth Isoforms Were Localized At Focal Adhesion And Cell-Cell Adhesion SitesIsoform Beta: Cell JunctionNucleusVinexin Beta Was Also Found In The Nucleus |
| Alternative Antibody Names | Anti-Vinexin antibodyAnti-Sh3-Containing Adapter Molecule 1 antibodyAnti-Scam-1 antibodyAnti-Sorbin And Sh3 Domain-Containing Protein 3 antibodyAnti-SORBS3 antibodyAnti-SCAM1 antibody |
Information sourced from Uniprot.org
