| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SOCS2 |
| Gene ID: |
8835 |
| Uniprot ID: |
SOCS2_HUMAN |
| Immunogen Region: |
1-198 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SOCS2 (NP_001257400.1). |
| Immunogen Sequence: |
MTLRCLEPSGNGGEGTRSQW GTAGSAEEPSPQAARLAKAL RELGQTGWYWGSMTVNEAKE KLKEAPEGTFLIRDSSHSDY LLTISVKTSAGPTNLRIEYQ DGKFRLDSIICVKSKLKQFD SVVHLIDYYVQMCKDKRTGP EAPRNGTVHLYLTKPLYTSA PSLQHLCRLTINKCTGAIWG LPLPTRLKDYLEEYKFQV |
| Tissue Specificity | High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes. |
| Post Translational Modifications | Ubiquitinated.mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC. Ubiquitination is stimulated by LPS. Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation. |
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR. |
| Protein Name | Suppressor Of Cytokine Signaling 2Socs-2Cytokine-Inducible Sh2 Protein 2Cis-2Stat-Induced Stat Inhibitor 2Ssi-2 |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-8951664Reactome: R-HSA-9706369Reactome: R-HSA-982772 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 2 antibodyAnti-Socs-2 antibodyAnti-Cytokine-Inducible Sh2 Protein 2 antibodyAnti-Cis-2 antibodyAnti-Stat-Induced Stat Inhibitor 2 antibodyAnti-Ssi-2 antibodyAnti-SOCS2 antibodyAnti-CIS2 antibodyAnti-SSI2 antibodyAnti-STATI2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
