Anti-SNX9 antibody (STJA0006958)

SKU:
STJA0006958

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sorting nexin-9 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SNX9
Gene ID: 51429
Uniprot ID: SNX9_HUMAN
Specificity: This antibody detects endogenous levels of SNX9 at Human, Mouse
Immunogen: Synthesized peptide derived from human SNX9
Post Translational Modifications Ubiquitinated by ITCH. Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.
Function Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
Protein Name Sorting Nexin-9
Sh3 And Px Domain-Containing Protein 1
Protein Sdp1
Sh3 And Px Domain-Containing Protein 3a
Database Links Reactome: R-HSA-432722
Reactome: R-HSA-8856828
Cellular Localisation Cytoplasmic Vesicle Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Membrane
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Golgi Apparatus
Trans-Golgi Network
Cell Projection
Ruffle
Cytoplasm
Localized At Sites Of Endocytosis At The Cell Membrane
Detected On Newly Formed Macropinosomes
Transiently Recruited To Clathrin-Coated Pits At A Late Stage Of Clathrin-Coated Vesicle Formation
Colocalizes With The Actin Cytoskeleton At The Cell Membrane
Alternative Antibody Names Anti-Sorting Nexin-9 antibody
Anti-Sh3 And Px Domain-Containing Protein 1 antibody
Anti-Protein Sdp1 antibody
Anti-Sh3 And Px Domain-Containing Protein 3a antibody
Anti-SNX9 antibody
Anti-SH3PX1 antibody
Anti-SH3PXD3A antibody

Information sourced from Uniprot.org

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