| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNX9 |
| Gene ID: | 51429 |
| Uniprot ID: | SNX9_HUMAN |
| Immunogen Region: | 1-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SNX9 (NP_057308.1). |
| Immunogen Sequence: | MATKARVMYDFAAEPGNNEL TVNEGEIITITNPDVGGGWL EGRNIKGERGLVPTDYVEIL PSDGKDQFSCGNSVADQAFL DSLSASTAQASSSAASNNHQ VGSGNDPWSAWSASKSGNWE SSEGWGAQPEGAGAQRNTNT PNNWDTAFGHPQAYQGPATG DDDDWDEDWDGPKSSSYFKD SESADAGGAQRGNSRASSSS MKIPLNKFPG |
| Tissue Specificity | Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes. |
| Post Translational Modifications | Ubiquitinated by ITCH. Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR. |
| Function | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. |
| Protein Name | Sorting Nexin-9 Sh3 And Px Domain-Containing Protein 1 Protein Sdp1 Sh3 And Px Domain-Containing Protein 3a |
| Database Links | Reactome: R-HSA-432722 Reactome: R-HSA-8856828 |
| Cellular Localisation | Cytoplasmic Vesicle Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Membrane Cytoplasmic Vesicle Clathrin-Coated Vesicle Golgi Apparatus Trans-Golgi Network Cell Projection Ruffle Cytoplasm Localized At Sites Of Endocytosis At The Cell Membrane Detected On Newly Formed Macropinosomes Transiently Recruited To Clathrin-Coated Pits At A Late Stage Of Clathrin-Coated Vesicle Formation Colocalizes With The Actin Cytoskeleton At The Cell Membrane |
| Alternative Antibody Names | Anti-Sorting Nexin-9 antibody Anti-Sh3 And Px Domain-Containing Protein 1 antibody Anti-Protein Sdp1 antibody Anti-Sh3 And Px Domain-Containing Protein 3a antibody Anti-SNX9 antibody Anti-SH3PX1 antibody Anti-SH3PXD3A antibody |
Information sourced from Uniprot.org