| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SNX18 (445-624) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SNX18 |
| Gene ID: |
112574 |
| Uniprot ID: |
SNX18_HUMAN |
| Immunogen Region: |
445-624 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 445-624 of human SNX18 (NP_001096045.1). |
| Immunogen Sequence: |
LNHTANEFARKQVTGFKKEY QKVGQSFRGLSQAFELDQQA FSVGLNQAIAFTGDAYDAIG ELFAEQPRQDLDPVMDLLAL YQGHLANFPDIIHVQKGALT KVKESRRHVEEGKMEVQKAD GIQDRCNTISFATLAEIHHF HQIRVRDFKSQMQHFLQQQI IFFQKVTQKLEEALHKYDSV |
| Function | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A. |
| Protein Name | Sorting Nexin-18Sh3 And Px Domain-Containing Protein 3b |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | Endomembrane SystemPeripheral Membrane ProteinCytoplasmic SideEndosome MembraneRecycling Endosome MembraneCell MembraneCytoplasmic Vesicle MembraneLocalized At Sites Of Endocytosis At The Cell MembraneDetected On Newly Formed MacropinosomesPartially Colocalized With Clathrin And Dynamin At The Cell MembraneTransiently Recruited To Clathrin-Coated Pits At A Late Stage Of Clathrin-Coated Vesicle Formation |
| Alternative Antibody Names | Anti-Sorting Nexin-18 antibodyAnti-Sh3 And Px Domain-Containing Protein 3b antibodyAnti-SNX18 antibodyAnti-SH3PXD3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
