| Function | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation.the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking. |
| Protein Name | Sorting Nexin-1 |
| Database Links | |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinCytoplasmic SideGolgi ApparatusTrans-Golgi Network MembraneEarly Endosome MembraneCell ProjectionLamellipodiumEnriched On Tubular Elements Of The Early Endosome MembraneBinds Preferentially To Highly Curved Membranes Enriched In Phosphatidylinositol 3-Phosphate (Ptdins(3p)) Or Phosphatidylinositol 35-Bisphosphate (Ptdins(35)P2)Colocalized With Sort1 To Tubular Endosomal Membrane Structures Called Endosome-To-Tgn Transport Carriers (Etcs) Which Are Budding From Early Endosome Vacuoles Just Before Maturing Into Late Endosome VacuolesColocalizes With Dnajc13 And Shiginella Dysenteria Toxin Stxb On Early EndosomesColocalized With F-Actin At The Leading Edge Of Lamellipodia In A Kalrn-Dependent Manner |
| Alternative Antibody Names | Anti-Sorting Nexin-1 antibodyAnti-SNX1 antibody |
Information sourced from Uniprot.org
