Anti-SMURF1 antibody (STJA0009791)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SMURF1
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase SMURF1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMURF1 |
| Gene ID | 57154 |
| Uniprot ID | SMUF1_HUMAN |
| Immunogen | Synthesized peptide derived from human SMURF1 |
| Specificity | This antibody detects endogenous levels of SMURF1 at Human, Mouse |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated in presence of NDFIP1. Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site. |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation. Plays a role in dendrite formation by melanocytes. |
| Protein Name | E3 Ubiquitin-Protein Ligase Smurf1Hsmurf1Hect-Type E3 Ubiquitin Transferase Smurf1Smad Ubiquitination Regulatory Factor 1Smad-Specific E3 Ubiquitin-Protein Ligase 1 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2173788Reactome: R-HSA-2173791Reactome: R-HSA-4608870Reactome: R-HSA-5632684Reactome: R-HSA-8939902Reactome: R-HSA-8941858Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Smurf1 antibodyAnti-Hsmurf1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Smurf1 antibodyAnti-Smad Ubiquitination Regulatory Factor 1 antibodyAnti-Smad-Specific E3 Ubiquitin-Protein Ligase 1 antibodyAnti-SMURF1 antibodyAnti-KIAA1625 antibody |
Information sourced from Uniprot.org