| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SMURF1 |
| Gene ID: |
57154 |
| Uniprot ID: |
SMUF1_HUMAN |
| Immunogen Region: |
150-250 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SMURF1 (NP_001186776.1). |
| Immunogen Sequence: |
VDCRGLLENEGTVYEDSGPG RPLSCFMEEPAPYTDSTGAA AGGGNCRFVESPSQDQRLQA QRLRNPDVRGSLQTPQNRPH GHQSPELPEGYEQRTTVQGQ V |
| Tissue Specificity | Expressed in melanocytes. |
| Post Translational Modifications | Auto-ubiquitinated in presence of NDFIP1. Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site. |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation. Plays a role in dendrite formation by melanocytes. |
| Protein Name | E3 Ubiquitin-Protein Ligase Smurf1Hsmurf1Hect-Type E3 Ubiquitin Transferase Smurf1Smad Ubiquitination Regulatory Factor 1Smad-Specific E3 Ubiquitin-Protein Ligase 1 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2173788Reactome: R-HSA-2173791Reactome: R-HSA-4608870Reactome: R-HSA-5632684Reactome: R-HSA-8939902Reactome: R-HSA-8941858Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Smurf1 antibodyAnti-Hsmurf1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Smurf1 antibodyAnti-Smad Ubiquitination Regulatory Factor 1 antibodyAnti-Smad-Specific E3 Ubiquitin-Protein Ligase 1 antibodyAnti-SMURF1 antibodyAnti-KIAA1625 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
