| Tissue Specificity | Predominantly expressed in brain. |
| Post Translational Modifications | Palmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation. |
| Function | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions. |
| Protein Name | Sphingomyelin Phosphodiesterase 3Neutral Sphingomyelinase 2Nsmase-2Nsmase2Neutral Sphingomyelinase Ii |
| Database Links | Reactome: R-HSA-5626978Reactome: R-HSA-9840310 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorCell MembraneMay Localize To Detergent-Resistant Subdomains Of Golgi Membranes Of Hypothalamic Neurosecretory NeuronsLocalizes To Plasma Membrane In Confluent Contact-Inhaibited Cells |
| Alternative Antibody Names | Anti-Sphingomyelin Phosphodiesterase 3 antibodyAnti-Neutral Sphingomyelinase 2 antibodyAnti-Nsmase-2 antibodyAnti-Nsmase2 antibodyAnti-Neutral Sphingomyelinase Ii antibodyAnti-SMPD3 antibody |
Information sourced from Uniprot.org
