| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP4R3A |
| Gene ID: | 55671 |
| Uniprot ID: | P4R3A_HUMAN |
| Immunogen Region: | 395-594 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 395-594 of human SMEK1 (NP_001271210.1). |
| Immunogen Sequence: | VQTFKGLKLRFEQQRERQDN PKLDSMRSILRNHRYRRDAR TLEDEEEMWFNTDEDDMEDG EAVVSPSDKTKNDDDIMDPI SKFMERKKLKESEEKEVLLK TNLSGRQSPSFKLSLSSGTK TNLTSQSSTTNLPGSPGSPG SPGSPGSPGSVPKNTSQTAA ITTKGGLVGLVDYPDDDEDD DEDEDKEDTLPLSKKAKFDS |
| Function | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. |
| Protein Name | Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 3aSmek Homolog 1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusIn Interphase Localized In The Cytoplasm And In The Nucleus (With Higher Levels)During Metaphase Located In Pericentriolar Regions |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 3a antibodyAnti-Smek Homolog 1 antibodyAnti-PPP4R3A antibodyAnti-KIAA2010 antibodyAnti-PP4R3A antibodyAnti-SMEK1 antibodyAnti-MSTP033 antibody |
Information sourced from Uniprot.org