| Post Translational Modifications | Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4. Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm. |
| Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. |
| Protein Name | Mothers Against Decapentaplegic Homolog 1Mad Homolog 1Mothers Against Dpp Homolog 1Jv4-1Mad-Related Protein 1Smad Family Member 1Smad 1Smad1Hsmad1Transforming Growth Factor-Beta-Signaling Protein 1Bsp-1 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-5689880Reactome: R-HSA-8941326 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic In The Absence Of LigandMigrates To The Nucleus When Complexed With Smad4Co-Localizes With Lemd3 At The Nucleus Inner MembraneExported From The Nucleus To The Cytoplasm When Dephosphorylated |
| Alternative Antibody Names | Anti-Mothers Against Decapentaplegic Homolog 1 antibodyAnti-Mad Homolog 1 antibodyAnti-Mothers Against Dpp Homolog 1 antibodyAnti-Jv4-1 antibodyAnti-Mad-Related Protein 1 antibodyAnti-Smad Family Member 1 antibodyAnti-Smad 1 antibodyAnti-Smad1 antibodyAnti-Hsmad1 antibodyAnti-Transforming Growth Factor-Beta-Signaling Protein 1 antibodyAnti-Bsp-1 antibodyAnti-SMAD1 antibodyAnti-BSP1 antibodyAnti-MADH1 antibodyAnti-MADR1 antibody |
Information sourced from Uniprot.org
