| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLIT1 |
| Gene ID: | 6585 |
| Uniprot ID: | SLIT1_HUMAN |
| Immunogen Region: | 1315-1534 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1315-1534 of human SLIT1 (NP_003052.2). |
| Immunogen Sequence: | RNLYINNELQDFTKTQMKPG VVPGCEPCRKLYCLHGICQP NATPGPMCHCEAGWVGLHCD QPADGPCHGHKCVHGQCVPL DALSYSCQCQDGYSGALCNQ AGALAEPCRGLQCLHGHCQA SGTKGAHCVCDPGFSGELCE QESECRGDPVRDFHQVQRGY AICQTTRPLSWVECRGSCPG QGCCQGLRLKRRKFTFECSD GTSFAEEVEKPTKCGCALCA |
| Tissue Specificity | Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. |
| Function | Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. |
| Protein Name | Slit Homolog 1 ProteinSlit-1Multiple Epidermal Growth Factor-Like Domains Protein 4Multiple Egf-Like Domains Protein 4 |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376176Reactome: R-HSA-428542Reactome: R-HSA-8985801Reactome: R-HSA-9010553 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Slit Homolog 1 Protein antibodyAnti-Slit-1 antibodyAnti-Multiple Epidermal Growth Factor-Like Domains Protein 4 antibodyAnti-Multiple Egf-Like Domains Protein 4 antibodyAnti-SLIT1 antibodyAnti-KIAA0813 antibodyAnti-MEGF4 antibodyAnti-SLIL1 antibody |
Information sourced from Uniprot.org