| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Solute carrier organic anion transporter family member 4C1 (77-127 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLCO4C1 |
| Gene ID: |
353189 |
| Uniprot ID: |
SO4C1_HUMAN |
| Immunogen Region: |
77-127 aa |
| Specificity: |
This antibody detects endogenous levels of SO4C1 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human SO4C1 at the amino acid range 77-127 |
| Function | Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney. Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate. Transport is independent of sodium, chloride ion, and ATP. Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter. The driving force for this transport activity is currently not known. The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined. Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption. Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker). Can act bidirectionally, suggesting a dual protective role of this transport protein.exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg. |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 4c1Slco4c1Oatp-HOrganic Anion Transporter M1Oatp-M1Organic Anion Transporting Polypeptide 4c1Oatp4c1Solute Carrier Family 21 Member 20 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-879518 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinDetected At The Basolateral Membrane Of The Proximal Tubule Cell In The Kidney |
| Alternative Antibody Names | Anti-Solute Carrier Organic Anion Transporter Family Member 4c1 antibodyAnti-Slco4c1 antibodyAnti-Oatp-H antibodyAnti-Organic Anion Transporter M1 antibodyAnti-Oatp-M1 antibodyAnti-Organic Anion Transporting Polypeptide 4c1 antibodyAnti-Oatp4c1 antibodyAnti-Solute Carrier Family 21 Member 20 antibodyAnti-SLCO4C1 antibodyAnti-OATP4C1 antibodyAnti-OATPX antibodyAnti-SLC21A20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
