| Function | Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner. May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta. The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 4a1Oatp4a1Colon Organic Anion TransporterOrganic Anion Transporter Polypeptide-Related Protein 1Oatp-Rp1Oatprp1PoatOrganic Anion-Transporting Polypeptide EOatp-ESodium-Independent Organic Anion Transporter ESolute Carrier Family 21 Member 12 |
| Database Links | Reactome: R-HSA-879518 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Organic Anion Transporter Family Member 4a1 antibodyAnti-Oatp4a1 antibodyAnti-Colon Organic Anion Transporter antibodyAnti-Organic Anion Transporter Polypeptide-Related Protein 1 antibodyAnti-Oatp-Rp1 antibodyAnti-Oatprp1 antibodyAnti-Poat antibodyAnti-Organic Anion-Transporting Polypeptide E antibodyAnti-Oatp-E antibodyAnti-Sodium-Independent Organic Anion Transporter E antibodyAnti-Solute Carrier Family 21 Member 12 antibodyAnti-SLCO4A1 antibodyAnti-OATP1 antibodyAnti-OATP4A1 antibodyAnti-OATPE antibodyAnti-SLC21A12 antibody |
Information sourced from Uniprot.org
