| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Solute carrier organic anion transporter family member 1C1 (634-684 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLCO1C1 |
| Gene ID: | 53919 |
| Uniprot ID: | SO1C1_HUMAN |
| Immunogen Region: | 634-684 aa |
| Specificity: | This antibody detects endogenous levels of SO1C1 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human SO1C1 at the amino acid range 634-684 |
| Function | Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane. Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases. Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency. Transports T4 and E1S in a pH-insensitive manner. Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain. |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 1c1 Organic Anion Transporter 1c1 Oatp1c1 Organic Anion Transporter F Oatp-F Organic Anion Transporter Polypeptide-Related Protein 5 Oat-Rp-5 Oatp-Rp5 Organic Anion-Transporting Polypeptide 14 Oatp-14 Solute Carrier Family 21 Member 14 Thyroxine Transporter |
| Database Links | Reactome: R-HSA-879518 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Expressed In Both Luminal And Abluminal Membranes Of Brain Capillary Endothelial Cells Localized To The Apical Membrane And Basal Surfaces Of Choroid Plexus |
| Alternative Antibody Names | Anti-Solute Carrier Organic Anion Transporter Family Member 1c1 antibody Anti-Organic Anion Transporter 1c1 antibody Anti-Oatp1c1 antibody Anti-Organic Anion Transporter F antibody Anti-Oatp-F antibody Anti-Organic Anion Transporter Polypeptide-Related Protein 5 antibody Anti-Oat-Rp-5 antibody Anti-Oatp-Rp5 antibody Anti-Organic Anion-Transporting Polypeptide 14 antibody Anti-Oatp-14 antibody Anti-Solute Carrier Family 21 Member 14 antibody Anti-Thyroxine Transporter antibody Anti-SLCO1C1 antibody Anti-OATP14 antibody Anti-OATP1C1 antibody Anti-OATPF antibody Anti-SLC21A14 antibody |
Information sourced from Uniprot.org