| Post Translational Modifications | Ubiquitinated (in vitro). Glycosylated. |
| Function | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo. Plays a critical role during neurodevelopment by regulating synaptic development and plasticity. Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH. Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane. |
| Protein Name | Sodium/Hydrogen Exchanger 6Na(+/H(+ Exchanger 6Nhe-6Solute Carrier Family 9 Member 6 |
| Database Links | Reactome: R-HSA-425986Reactome: R-HSA-5619092 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneEarly Endosome MembraneLate Endosome MembraneCell MembranePresent Predominantly In The Recycling Compartments Including Early And Recycling EndosomesBut Undergoes Plasma Membrane Localization During Vesicular RecyclingWhich Is Enhanced Upon Certain StimuliSuch As HypoxiaHas A Major Plasmalemmal Distribution In A Few Specialized CellsSuch As In Vestibular Hair Bundles And Osteoblasts |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 6 antibodyAnti-Na(+/H(+ Exchanger 6 antibodyAnti-Nhe-6 antibodyAnti-Solute Carrier Family 9 Member 6 antibodyAnti-SLC9A6 antibodyAnti-KIAA0267 antibodyAnti-NHE6 antibody |
Information sourced from Uniprot.org
