| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC8A1 (420-470 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1: 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SLC8A1 |
| Gene ID: |
6546 |
| Uniprot ID: |
NAC1_HUMAN |
| Immunogen Region: |
420-470 aa |
| Specificity: |
Specific for SLC8A1. |
| Immunogen: |
A synthetic peptide from aa region 420-470 of human SLC8A1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Function | Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. |
| Protein Name | Sodium/Calcium Exchanger 1Na(+/Ca(2+-Exchange Protein 1Solute Carrier Family 8 Member 1 |
| Database Links | Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-5578775 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Calcium Exchanger 1 antibodyAnti-Na(+/Ca(2+-Exchange Protein 1 antibodyAnti-Solute Carrier Family 8 Member 1 antibodyAnti-SLC8A1 antibodyAnti-CNC antibodyAnti-NCX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
