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Anti-SLC6A3-Extracellular Loop 2 antibody (Extracellular Loop 2 Region) (STJA0003617)

Western blot of human striatal lysate showing specific immunolabeling of the ~88 kDa DAT protein.

Anti-SLC6A3-Extracellular Loop 2 antibody (Extracellular Loop 2 Region) (STJA0003617)

SKU:

STJA0003617-100

£442.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Non-Human Primates
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Dopamine Transporter-Extracellular Loop 2 (Extracellular Loop 2 Region) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification:	This antibody was antigen affinity purified from pooled serum.
Dilution Range:	WB 1:1000 IHC 1:1000 ICC IP
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SLC6A3
Gene ID:	6531
Uniprot ID:	SC6A3_HUMAN
Immunogen Region:	Extracellular Loop 2 Region
Immunogen:	Synthetic peptide corresponding to amino acid residues from the extracellular loop 2 region conjugated to KLH.

Tissue Specificity	Highly expressed in substantia nigra. Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level). Expressed in the striatum (at protein level).
Function	Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling.
Protein Name	Sodium-Dependent Dopamine Transporter Da Transporter Dat Solute Carrier Family 6 Member 3
Database Links	Reactome: R-HSA-379401 Reactome: R-HSA-442660 Reactome: R-HSA-5619081 Reactome: R-HSA-5660724
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Projection Neuron Projection Axon Localizes To Neurite Tips In Neuronal Cells Colocalizes With Septin4 At Axon Terminals Especially At The Varicosities
Alternative Antibody Names	Anti-Sodium-Dependent Dopamine Transporter antibody Anti-Da Transporter antibody Anti-Dat antibody Anti-Solute Carrier Family 6 Member 3 antibody Anti-SLC6A3 antibody Anti-DAT1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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