Western blot analysis of extracts of 293T cells, using SLC6A12 antibody (STJ112414) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-SLC6A12 antibody (515-614) (STJ112414)

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STJ112414
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC6A12
Gene ID: 6539
Uniprot ID: S6A12_HUMAN
Immunogen Region: 515-614
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 515-614 of human SLC6A12 (NP_003035.3).
Immunogen Sequence: FSLSKYTPLKYNNVYVYPPW GYSIGWFLALSSMVCVPLFV VITLLKTRGPFRKRLRQLIT PDSSLPQPKQHPCLDGSAGR NFGPSPTREGLIAGEKETHL
Tissue Specificity Expressed in kidney, liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.
Function Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation.
Protein Name Sodium- And Chloride-Dependent Betaine Transporter
Bgt-1
Na(+/Cl(- Betaine/Gaba Transporter
Solute Carrier Family 6 Member 12
Database Links Reactome: R-HSA-352230
Reactome: R-HSA-442660
Reactome: R-HSA-71288
Reactome: R-HSA-888593
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
In Kidney
Locates In Basolateral Membranes Of Renal Medulla
In Liver
Locates In Hepatocytes Cell Membrane
Alternative Antibody Names Anti-Sodium- And Chloride-Dependent Betaine Transporter antibody
Anti-Bgt-1 antibody
Anti-Na(+/Cl(- Betaine/Gaba Transporter antibody
Anti-Solute Carrier Family 6 Member 12 antibody
Anti-SLC6A12 antibody
Anti-BGT1 antibody

Information sourced from Uniprot.org

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