| Short Description : | Rabbit polyclonal SLC6A1 (500-599) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC6A1 |
| Gene ID: | 6529 |
| Uniprot ID: | SC6A1_HUMAN |
| Immunogen Region: | 500-599 |
| Immunogen Sequence: | WSFFTPIIVAGVFIFSAVQM TPLTMGNYVFPKWGQGVGWL MALSSMVLIPGYMAYMFLTL KGSLKQRIQVMVQPSEDIVR PENGPEQPQAGSSTSKEAYI |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 500-599 of human SLC6A1 (NP_003033.3). |
| Function | Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA. The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA. Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA. |
| Protein Name | Sodium- And Chloride-Dependent Gaba Transporter 1Gat-1Solute Carrier Family 6 Member 1 |
| Database Links | Reactome: R-HSA-442660Reactome: R-HSA-888593 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPresynapseLocalized At The Presynaptic Terminals Of Interneurons |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Gaba Transporter 1 antibodyAnti-Gat-1 antibodyAnti-Solute Carrier Family 6 Member 1 antibodyAnti-SLC6A1 antibodyAnti-GABATR antibodyAnti-GABT1 antibodyAnti-GAT1 antibody |
Information sourced from Uniprot.org
