| Function | Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA. The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA. Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA. |
| Protein Name | Sodium- And Chloride-Dependent Gaba Transporter 1Gat-1Solute Carrier Family 6 Member 1 |
| Database Links | Reactome: R-HSA-442660Reactome: R-HSA-888593 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPresynapseLocalized At The Presynaptic Terminals Of Interneurons |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Gaba Transporter 1 antibodyAnti-Gat-1 antibodyAnti-Solute Carrier Family 6 Member 1 antibodyAnti-SLC6A1 antibodyAnti-GABATR antibodyAnti-GABT1 antibodyAnti-GAT1 antibody |
Information sourced from Uniprot.org
