| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SLC45A2 (1st Cytoplasmic Domain) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | SLC45A2 |
| Gene ID: | 51151 |
| Uniprot ID: | S45A2_HUMAN |
| Immunogen Region: | 1st Cytoplasmic Domain |
| Specificity: | Specific for SLC45A2. |
| Immunogen: | A synthetic peptide from 1t cytoplasmic domain of human SLC45A2 (Melanoma antigen AIM1) conjugated to blue carrier protein was used as the antigen. |
| Function | Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis. Regulates melanogenesis by maintaining melanosome neutralization that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR. |
| Protein Name | Membrane-Associated Transporter ProteinMelanoma Antigen Aim1Protein Aim-1Solute Carrier Family 45 Member 2 |
| Database Links | Reactome: R-HSA-5662702 |
| Cellular Localisation | Melanosome MembraneMulti-Pass Membrane ProteinEnriched In Mature Melanocyte Membrane Subdomains |
| Alternative Antibody Names | Anti-Membrane-Associated Transporter Protein antibodyAnti-Melanoma Antigen Aim1 antibodyAnti-Protein Aim-1 antibodyAnti-Solute Carrier Family 45 Member 2 antibodyAnti-SLC45A2 antibodyAnti-AIM1 antibodyAnti-MATP antibody |
Information sourced from Uniprot.org