| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC40A1 (250-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC40A1 |
| Gene ID: |
30061 |
| Uniprot ID: |
S40A1_HUMAN |
| Immunogen Region: |
250-300 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 250-300 of human SLC40A1 (NP_055400.1). |
| Immunogen Sequence: |
NLHKDTEPKPLEGTHLMGVK DSNIHELEHEQEPTCASQMA EPFRTFRDGWV |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen. Highly expressed in mature red blood. |
| Post Translational Modifications | Polyubiquitinated by RNF217.leading to proteasomal degradation. Ubiquitination is necessary for its internalization by hepcidin/HAMP. |
| Function | Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes. When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma. |
| Protein Name | Solute Carrier Family 40 Member 1Ferroportin-1Iron-Regulated Transporter 1 |
| Database Links | Reactome: R-HSA-425410Reactome: R-HSA-5619049Reactome: R-HSA-5619060Reactome: R-HSA-5655799Reactome: R-HSA-917937 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocalized To The Basolateral Membrane Of Hepatocytoma Wif-B Cells |
| Alternative Antibody Names | Anti-Solute Carrier Family 40 Member 1 antibodyAnti-Ferroportin-1 antibodyAnti-Iron-Regulated Transporter 1 antibodyAnti-SLC40A1 antibodyAnti-FPN antibodyAnti-FPN1 antibodyAnti-IREG1 antibodyAnti-SLC11A3 antibodyAnti-MSTP079 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
