| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC40A1 |
| Gene ID: | 30061 |
| Uniprot ID: | S40A1_HUMAN |
| Immunogen Region: | 250-300 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 250-300 of human SLC40A1 (NP_055400.1). |
| Immunogen Sequence: | NLHKDTEPKPLEGTHLMGVK DSNIHELEHEQEPTCASQMA EPFRTFRDGWV |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen. Highly expressed in mature red blood. |
| Post Translational Modifications | Polyubiquitinated by RNF217.leading to proteasomal degradation. Under conditions of high systemic iron levels, both the hormone peptide hepcidin/HAMP and holo(iron bound)-transferrin/TF induce the ubiquitination, internalization and proteasomal degradation of SLC40A1 to control iron release from cells. |
| Function | Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes. When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma. |
| Protein Name | Ferroportin Ferroportin-1 Iron-Regulated Transporter 1 Solute Carrier Family 40 Member 1 |
| Database Links | Reactome: R-HSA-425410 Reactome: R-HSA-5619049 Reactome: R-HSA-5619060 Reactome: R-HSA-5655799 Reactome: R-HSA-917937 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Localized To The Basolateral Membrane Of Hepatocytoma Wif-B Cells |
| Alternative Antibody Names | Anti-Ferroportin antibody Anti-Ferroportin-1 antibody Anti-Iron-Regulated Transporter 1 antibody Anti-Solute Carrier Family 40 Member 1 antibody Anti-SLC40A1 antibody Anti-FPN antibody Anti-FPN1 antibody Anti-IREG1 antibody Anti-SLC11A3 antibody Anti-MSTP079 antibody |
Information sourced from Uniprot.org