Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Amino acid transporter heavy chain SLC3A2 (491-540 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | SLC3A2 |
Gene ID: | 6520 |
Uniprot ID: | 4F2_HUMAN |
Immunogen Region: | 491-540 aa |
Specificity: | CD98 Polyclonal Antibody detects endogenous levels of CD98 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the C-terminal region of human SLC3A2 at the amino acid range 491-540 |
Post Translational Modifications | N-glycosylated.N-glycosylation is crucial for trafficking and stability of SLC3A2 to the plasma membrane. Phosphorylation on Ser-406.Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions. |
Function | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters. Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane. SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression. (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. |
Protein Name | Amino Acid Transporter Heavy Chain Slc3a2 4f2 Cell-Surface Antigen Heavy Chain 4f2hc 4f2 Heavy Chain Antigen Lymphocyte Activation Antigen 4f2 Large Subunit Solute Carrier Family 3 Member 2 Cd Antigen Cd98 |
Database Links | Reactome: R-HSA-210991 Reactome: R-HSA-352230 Reactome: R-HSA-5660862 Reactome: R-HSA-71240 |
Cellular Localisation | Apical Cell Membrane Cell Membrane Single-Pass Type Ii Membrane Protein Cell Junction Lysosome Membrane Melanosome Basolateral Cell Membrane Localized At The Plasma Membrane When Associated With Slc7a5/Lat1 Or Slc7a8/Lat2 Localized To The Apical Membrane Of Placental Syncytiotrophoblastic Cells Recruited To Lysosomes By Laptm4b Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv Located Selectively At Cell-Cell Adhesion Sites Colocalized With Slc7a8/Lat2 At The Basolateral Membrane Of Kidney Proximal Tubules And Small Intestine Epithelia Expressed In Both Luminal And Abluminal Membranes Of Brain Capillary Endothelial Cells |
Alternative Antibody Names | Anti-Amino Acid Transporter Heavy Chain Slc3a2 antibody Anti-4f2 Cell-Surface Antigen Heavy Chain antibody Anti-4f2hc antibody Anti-4f2 Heavy Chain Antigen antibody Anti-Lymphocyte Activation Antigen 4f2 Large Subunit antibody Anti-Solute Carrier Family 3 Member 2 antibody Anti-Cd Antigen Cd98 antibody Anti-SLC3A2 antibody Anti-MDU1 antibody |
Information sourced from Uniprot.org