| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Zinc transporter SLC39A7 (131-180 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC39A7 |
| Gene ID: | 7922 |
| Uniprot ID: | S39A7_HUMAN |
| Immunogen Region: | 131-180 aa |
| Specificity: | ZIP7 Polyclonal Antibody detects endogenous levels of ZIP7 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SLC39A7 at the amino acid range 131-180 |
| Post Translational Modifications | Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release. Methylation at some His residue by METTL9 leads to reduced zinc-binding. |
| Function | Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling. Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle. Has a protective role against ER stress in different biological contexts. Mediates Zn(2+)-induced ferroptosis. |
| Protein Name | Zinc Transporter Slc39a7 Histidine-Rich Membrane Protein Ke4 Really Interesting New Gene 5 Protein Solute Carrier Family 39 Member 7 Zrt- - Irt-Like Protein 7 Zip7 |
| Database Links | Reactome: R-HSA-442380 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Golgi Apparatus Cis-Golgi Network Membrane |
| Alternative Antibody Names | Anti-Zinc Transporter Slc39a7 antibody Anti-Histidine-Rich Membrane Protein Ke4 antibody Anti-Really Interesting New Gene 5 Protein antibody Anti-Solute Carrier Family 39 Member 7 antibody Anti-Zrt- - Irt-Like Protein 7 antibody Anti-Zip7 antibody Anti-SLC39A7 antibody Anti-HKE4 antibody Anti-RING5 antibody |
Information sourced from Uniprot.org