| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Zinc transporter ZIP6 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC39A6 |
| Gene ID: | 25800 |
| Uniprot ID: | S39A6_HUMAN |
| Specificity: | S39A6 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. |
| Function | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition. |
| Protein Name | Zinc Transporter Zip6 Estrogen-Regulated Protein Liv-1 Solute Carrier Family 39 Member 6 Zrt- And Irt-Like Protein 6 Zip-6 |
| Database Links | Reactome: R-HSA-442380 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Lamellipodium Membrane Membrane Raft Apical Cell Membrane Localizes To Lipid Rafts In T Cells And Is Recruited Into The Immunological Synapse In Response To Tcr Stimulation In The Choroid Plexus Is Limited To The Apical Membrane In Epithelial Cells |
| Alternative Antibody Names | Anti-Zinc Transporter Zip6 antibody Anti-Estrogen-Regulated Protein Liv-1 antibody Anti-Solute Carrier Family 39 Member 6 antibody Anti-Zrt- And Irt-Like Protein 6 antibody Anti-Zip-6 antibody Anti-SLC39A6 antibody Anti-LIV1 antibody Anti-ZIP6 antibody |
Information sourced from Uniprot.org