Anti-SLC39A6 antibody (400-500 aa) (STJ13102241)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 400-500 human SLC39A6 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC39A6 (400-500 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC39A6 |
| Gene ID | 25800 |
| Uniprot ID | S39A6_HUMAN |
| Immunogen | A synthetic peptide from aa region 400-500 human SLC39A6 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 400-500 aa |
| Specificity | Specific for SLC39A6. |
Additional Info
| Post Translational Modifications | Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. |
| Function | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition. |
| Protein Name | Zinc Transporter Zip6Estrogen-Regulated Protein Liv-1Solute Carrier Family 39 Member 6Zrt- And Irt-Like Protein 6Zip-6 |
| Database Links | Reactome: R-HSA-442380 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionLamellipodium MembraneMembrane RaftApical Cell MembraneLocalizes To Lipid Rafts In T Cells And Is Recruited Into The Immunological Synapse In Response To Tcr StimulationIn The Choroid Plexus Is Limited To The Apical Membrane In Epithelial Cells |
| Alternative Antibody Names | Anti-Zinc Transporter Zip6 antibodyAnti-Estrogen-Regulated Protein Liv-1 antibodyAnti-Solute Carrier Family 39 Member 6 antibodyAnti-Zrt- And Irt-Like Protein 6 antibodyAnti-Zip-6 antibodyAnti-SLC39A6 antibodyAnti-LIV1 antibodyAnti-ZIP6 antibody |
Information sourced from Uniprot.org