Anti-SLC39A5 antibody (STJ191654)

SKU:
STJ191654

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Zinc transporter ZIP5 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC39A5
Gene ID: 283375
Uniprot ID: S39A5_HUMAN
Specificity: S39A5 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Methylated at His-375 by METTL9. N-Glycosylated.
Function Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine. The transport mechanism is temperature- and concentration-dependent and saturable. In addition, is also a high affinity copper transporter in vitro. Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Plays a role in eye development.
Protein Name Zinc Transporter Zip5
Solute Carrier Family 39 Member 5
Zrt- And Irt-Like Protein 5
Zip-5
Database Links Reactome: R-HSA-442380
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Localized To The Basolateral Surfaces Of Enterocytes
Pancreatic Acinar And Endoderm Cells
During Zinc Deficiency Diet
The Basolateral Cell Membrane Localization Is Lost In The Intestine
The Visceral Yolk Sac And Acinar Cell
During Zinc Repletion
Is Relocalized To The Basolateral Membrane Of Enterocytes
Visceral Endoderm Cells And Pancreatic Acinar Cells
Zinc Can Regulate The Turnover Of Protein At The Membrane
During Zinc Deficiency
Is Internalized And Degraded In Enterocytes
Acinar Cells And Endoderm Cells
Endocytosed Through The Endolysosomal Degradation Pathway Rab5a Pathway
Alternative Antibody Names Anti-Zinc Transporter Zip5 antibody
Anti-Solute Carrier Family 39 Member 5 antibody
Anti-Zrt- And Irt-Like Protein 5 antibody
Anti-Zip-5 antibody
Anti-SLC39A5 antibody
Anti-ZIP5 antibody

Information sourced from Uniprot.org

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