| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC30A5 (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1: 2000 is recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SLC30A5 |
| Gene ID: |
64924 |
| Uniprot ID: |
ZNT5_HUMAN |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for SLC30A5. |
| Immunogen: |
A synthetic peptide from internal cytoplasmic region of human Zinc transporter 5 (SLC30A5) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Post Translational Modifications | Could homodimerize through the formation of dityrosine bonds upon oxidative stress. |
| Function | Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin. Isoform 2: Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane. |
| Protein Name | Proton-Coupled Zinc Antiporter Slc30a5Solute Carrier Family 30 Member 5Zinc Transporter 5Znt-5Znt-Like Transporter 1Hztl1 |
| Database Links | Reactome: R-HSA-264876Reactome: R-HSA-435368 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleCopii-Coated Vesicle MembraneSecretory Vesicle MembraneTrans-Golgi Network MembraneEnriched In Early Compartments Of The Secretory Pathway Including Copii-Coated Vesicles And The Golgi Cis CisternaIsoform 2: Endoplasmic Reticulum MembraneCell MembraneApical Cell Membrane |
| Alternative Antibody Names | Anti-Proton-Coupled Zinc Antiporter Slc30a5 antibodyAnti-Solute Carrier Family 30 Member 5 antibodyAnti-Zinc Transporter 5 antibodyAnti-Znt-5 antibodyAnti-Znt-Like Transporter 1 antibodyAnti-Hztl1 antibodyAnti-SLC30A5 antibodyAnti-ZNT5 antibodyAnti-ZNTL1 antibodyAnti-ZTL1 antibodyAnti-UNQ863 antibodyAnti-PRO1879 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
