| Function | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (Probable). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells. In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them. Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER. Down-regulates the activity of transcription factors induced by zinc and cytokines. |
| Protein Name | Proton-Coupled Zinc Antiporter Slc30a1Solute Carrier Family 30 Member 1Zinc Transporter 1Znt-1 |
| Database Links | Reactome: R-MMU-435368 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCytoplasmic Vesicle MembraneCytoplasmEndoplasmic Reticulum MembraneGolgi Apparatus MembraneNucleus MembraneLocalization To The Plasma Membrane Is Regulated By Cellular Zinc StatusRecruitment To The Plasma Membrane From An Internal Pool Is Stimulated By Zinc While In Absence Of Zinc The Plasma Membrane Pool Is Endocytosed And DegradedLocalizes To The Basolateral Surface Of EnterocytesLocalizes To Zinc-Containing Intracellular Vesicles In MacrophagesLocalizes In The Cytoplasm And To The ErGolgi And Nucleus Membranes In Keratinocytes |
| Alternative Antibody Names | Anti-Proton-Coupled Zinc Antiporter Slc30a1 antibodyAnti-Solute Carrier Family 30 Member 1 antibodyAnti-Zinc Transporter 1 antibodyAnti-Znt-1 antibodyAnti-Slc30a1 antibodyAnti-Znt1 antibody |
Information sourced from Uniprot.org
