| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC30A1 (150-250 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Slc30a1 |
| Gene ID: |
22782 |
| Uniprot ID: |
ZNT1_MOUSE |
| Immunogen Region: |
150-250 aa |
| Specificity: |
Specific for SLC30A1. |
| Immunogen: |
A synthetic peptide from aa region 150-250 of mouse SLC30A1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (Probable). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells. In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them. Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER. Down-regulates the activity of transcription factors induced by zinc and cytokines. |
| Protein Name | Proton-Coupled Zinc Antiporter Slc30a1Solute Carrier Family 30 Member 1Zinc Transporter 1Znt-1 |
| Database Links | Reactome: R-MMU-435368 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCytoplasmic Vesicle MembraneCytoplasmEndoplasmic Reticulum MembraneGolgi Apparatus MembraneNucleus MembraneLocalization To The Plasma Membrane Is Regulated By Cellular Zinc StatusRecruitment To The Plasma Membrane From An Internal Pool Is Stimulated By Zinc While In Absence Of Zinc The Plasma Membrane Pool Is Endocytosed And DegradedLocalizes To The Basolateral Surface Of EnterocytesLocalizes To Zinc-Containing Intracellular Vesicles In MacrophagesLocalizes In The Cytoplasm And To The ErGolgi And Nucleus Membranes In Keratinocytes |
| Alternative Antibody Names | Anti-Proton-Coupled Zinc Antiporter Slc30a1 antibodyAnti-Solute Carrier Family 30 Member 1 antibodyAnti-Zinc Transporter 1 antibodyAnti-Znt-1 antibodyAnti-Slc30a1 antibodyAnti-Znt1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
