Anti-SLC29A4 antibody (404-454 aa) (STJ194839)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human S29A4 at the amino acid range 404-454
General Information
| Short Description | Rabbit polyclonal anti-Equilibrative nucleoside transporter 4 (404-454 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC29A4 |
| Gene ID | 222962 |
| Uniprot ID | S29A4_HUMAN |
| Immunogen | Synthesized peptide derived from the human S29A4 at the amino acid range 404-454 |
| Immunogen Region | 404-454 aa |
| Specificity | This antibody detects endogenous levels of S29A4 at Human/Mouse |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs. Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations. Functions as a Na(+)- and Cl(-)-independent bidirectional transporter. Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure. Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system. Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain. Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney. Also transports guanidine. |
| Protein Name | Equilibrative Nucleoside Transporter 4Hent4Plasma Membrane Monoamine TransporterPmatSolute Carrier Family 29 Member 4 |
| Database Links | Reactome: R-HSA-83936 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneLocated To The Plasma Membranes Of Ventricular Myocytes And Vascular Endothelial CellsTargeted To The Apical Membranes Of Differentiated Kidney Epithelial CellsLocalized To The Apical Blood-Cerebrospinal Fluid (Csf)-Facing Membrane Of The Choroid Plexus Epithelium |
| Alternative Antibody Names | Anti-Equilibrative Nucleoside Transporter 4 antibodyAnti-Hent4 antibodyAnti-Plasma Membrane Monoamine Transporter antibodyAnti-Pmat antibodyAnti-Solute Carrier Family 29 Member 4 antibodyAnti-SLC29A4 antibodyAnti-ENT4 antibodyAnti-PMAT antibodyAnti-PSEC0113 antibody |
Information sourced from Uniprot.org