| Short Description : | Rabbit polyclonal anti-Chloride anion exchanger (C-Term) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC26A3 |
| Gene ID: | 1811 |
| Uniprot ID: | S26A3_HUMAN |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human DRA. |
| Immunogen Region: | C-Term |
| Specificity: | DRA Polyclonal Antibody detects endogenous levels of DRA protein. |
| Post Translational Modifications | N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. |
| Function | Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. |
| Protein Name | Chloride Anion ExchangerDown-Regulated In AdenomaProtein DraSolute Carrier Family 26 Member 3 |
| Database Links | Reactome: R-HSA-427601Reactome: R-HSA-5619085 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinMembraneCell MembraneLocalized In Sperm MembranesMidpiece Of Sperm TailColocalizes With Cftr At The Midpiece Of Sperm Tail |
| Alternative Antibody Names | Anti-Chloride Anion Exchanger antibodyAnti-Down-Regulated In Adenoma antibodyAnti-Protein Dra antibodyAnti-Solute Carrier Family 26 Member 3 antibodyAnti-SLC26A3 antibodyAnti-DRA antibody |
Information sourced from Uniprot.org
