Anti-SLC26A3 antibody (520-570) {FITC} (STJ506232)

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STJ506232-100
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SLC26A3 (520-570) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality : Polyclonal
Conjugation: FITC
Isotype: IgG
Formulation: Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Purification: Affinity Purified
Concentration: 0.5-1.5 Mu g/Mu l
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:100
ICC: 1:50-1:100
IF: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC26A3
Gene ID: 1811
Uniprot ID: S26A3_HUMAN
Immunogen Region: 520-570
Immunogen: Synthetic peptide corresponding to amino acids within region 520-570 on human SCL26A3 protein.
Tissue Specificity Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.
Post Translational Modifications N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.
Function Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Protein Name Chloride Anion Exchanger
Down-Regulated In Adenoma
Protein Dra
Solute Carrier Family 26 Member 3
Database Links Reactome: R-HSA-427601
Reactome: R-HSA-5619085
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Membrane
Cell Membrane
Localized In Sperm Membranes
Midpiece Of Sperm Tail
Colocalizes With Cftr At The Midpiece Of Sperm Tail
Alternative Antibody Names Anti-Chloride Anion Exchanger antibody
Anti-Down-Regulated In Adenoma antibody
Anti-Protein Dra antibody
Anti-Solute Carrier Family 26 Member 3 antibody
Anti-SLC26A3 antibody
Anti-DRA antibody

Information sourced from Uniprot.org

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