| Tissue Specificity | High levels in liver and low levels in kidney, pancreas, placenta, heart and brain. |
| Function | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards gamma-aminobutyric acid (GABA). |
| Protein Name | Electrogenic Aspartate/Glutamate Antiporter Slc25a13 - MitochondrialCalcium-Binding Mitochondrial Carrier Protein Aralar2Aralar-Related Gene 2Aralar2CitrinMitochondrial Aspartate Glutamate Carrier 2Solute Carrier Family 25 Member 13 |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-8963693Reactome: R-HSA-9856872 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Electrogenic Aspartate/Glutamate Antiporter Slc25a13 - Mitochondrial antibodyAnti-Calcium-Binding Mitochondrial Carrier Protein Aralar2 antibodyAnti-Aralar-Related Gene 2 antibodyAnti-Aralar2 antibodyAnti-Citrin antibodyAnti-Mitochondrial Aspartate Glutamate Carrier 2 antibodyAnti-Solute Carrier Family 25 Member 13 antibodyAnti-SLC25A13 antibody |
Information sourced from Uniprot.org
