| Post Translational Modifications | Possesses a short cleavable presequence, which, however, is found to be dispensable both for targeting to mitochondria and insertion into the inner membrane. However, the presequence is required to keep SLC25A1 in a soluble state and thus in an import-competent state. Mature SLC25A1 lacking the presequence is prone to aggregation. |
| Function | Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate. In the cytoplasm citrate is important in the regulation of glycolysis through a feedback mechanism and in the production of acetyl-CoA which is needed for the synthesis of fatty acids, sterols, prostaglandins, dolichol and coenzyme Q (CoQ). Required for proper neuromuscular junction formation (Probable). |
| Protein Name | Tricarboxylate Transport Protein - MitochondrialCitrate Transport ProteinCtpMitochondrial Citrate CarrierCicSolute Carrier Family 25 Member 1Tricarboxylate Carrier Protein |
| Database Links | Reactome: R-HSA-428643 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tricarboxylate Transport Protein - Mitochondrial antibodyAnti-Citrate Transport Protein antibodyAnti-Ctp antibodyAnti-Mitochondrial Citrate Carrier antibodyAnti-Cic antibodyAnti-Solute Carrier Family 25 Member 1 antibodyAnti-Tricarboxylate Carrier Protein antibodyAnti-SLC25A1 antibodyAnti-SLC20A3 antibody |
Information sourced from Uniprot.org
