• Western blot analysis of the lysates from HeLa cells using SLC22A5 antibody.
  • Western blot analysis of SLC22A5 Antibody. The lane on the right is blocked with the SLC22A5 peptide.

Anti-SLC22A5 antibody (300-349) (STJ94600)

SKU:
STJ94600

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Organic cation/carnitine transporter 2 (300-349) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC22A5
Gene ID: 6584
Uniprot ID: S22A5_HUMAN
Immunogen Region: 300-349
Specificity: OCTN2 Polyclonal Antibody detects endogenous levels of OCTN2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human SLC22A5. AA range:300-349
Tissue Specificity Strongly expressed in kidney, skeletal muscle, heart and placenta. Primarily expressed by surface epithelial cells of the colon (at protein level). Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. In testis, localized to Sertoli cell basal membranes, peritubular myoid cells and Leydig cells.
Post Translational Modifications Glycosylated. Glycosylation affects the expression levels. Isoform 3: Not glycosylated.
Function Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3. In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from Bacillus Subtilis wich induces cytoprotective heat shock proteins contributing to intestinal homeostasis. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Isoform 3: Retained in the ER, unable to perform carnitine uptake.
Protein Name Organic Cation/Carnitine Transporter 2
High-Affinity Sodium-Dependent Carnitine Cotransporter
Solute Carrier Family 22 Member 5
Database Links Reactome: R-HSA-200425
Reactome: R-HSA-549127
Reactome: R-HSA-5619053
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Basal Cell Membrane
In Intestinal Cells
Apical Expression Is Induced By Tnf
Localized To The Basal Membrane Of Sertoli Cells
Isoform 3: Endoplasmic Reticulum
Alternative Antibody Names Anti-Organic Cation/Carnitine Transporter 2 antibody
Anti-High-Affinity Sodium-Dependent Carnitine Cotransporter antibody
Anti-Solute Carrier Family 22 Member 5 antibody
Anti-SLC22A5 antibody
Anti-OCTN2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance