| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC22A4 (42-141) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC22A4 |
| Gene ID: |
6583 |
| Uniprot ID: |
S22A4_HUMAN |
| Immunogen Region: |
42-141 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 42-141 of human SLC22A4 (NP_003050.2). |
| Immunogen Sequence: |
LAGTPEHRCRVPDAANLSSA WRNNSVPLRLRDGREVPHSC SRYRLATIANFSALGLEPGR DVDLGQLEQESCLDGWEFSQ DVYLSTVVTEWNLVCEDNWK |
| Tissue Specificity | Widely expressed. Highly expressed in kidney, trachea, ileum, bone marrow and whole blood. Expressed in small intestines. Weakly expressed in skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Expressed in testis, primarily to the basal membrane of Sertoli cells. Expressed in brain. Expressed in liver. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells. Expressed in fetal liver, kidney and lung. |
| Function | Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations. Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine. Transports one sodium ion with one ergothioeine molecule. Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body. Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet. Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system. Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports. May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis. May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier. |
| Protein Name | Solute Carrier Family 22 Member 4Ergothioneine TransporterEt TransporterEtthOrganic Cation/Carnitine Transporter 1Octn1 |
| Database Links | Reactome: R-HSA-549127 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneMitochondrion MembraneLocalized To The Apical Membrane Of Small IntestinesLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 4 antibodyAnti-Ergothioneine Transporter antibodyAnti-Et Transporter antibodyAnti-Etth antibodyAnti-Organic Cation/Carnitine Transporter 1 antibodyAnti-Octn1 antibodyAnti-SLC22A4 antibodyAnti-ETT antibodyAnti-OCTN1 antibodyAnti-UT2H antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
