| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC22A3 (289-349) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC22A3 |
| Gene ID: |
6581 |
| Uniprot ID: |
S22A3_HUMAN |
| Immunogen Region: |
289-349 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 289-349 of human SLC22A3/OCT3 (NP_068812.1). |
| Immunogen Sequence: |
PESPRWLITRKKGDKALQIL RRIAKCNGKYLSSNYSEITV TDEEVSNPSFLDLVRTPQMR K |
| Tissue Specificity | Expressed in liver. Expressed in intestine. Expressed in kidney in proximal tubular cells. Expressed in placenta. Expressed throughout the brain, including cerebral cortex, cerebrellum, substancia nigra, medulla oblongata, hippocampus, caudate nucleus, nucleus accumbens and pons with low levels of expression detected in nearly all brain regions. In testis, mostly localized to peritubular myoid cells and Leydig cells, and weakly expressed in developing germ cells. Expressed in tracheal and bronchial epithelium of the respiratory tract, where it localizes to the apical membrane of ciliated cells, the entire membrane of basal cells and the basolateral membrane of intermediate cells. Expressed in skeletal muscle, adrenal gland, heart, prostate, aorta, salivary gland, adrenal gland, uterus, lymph node, lung, trachea and spinal cord. Expressed in fetal lung and liver. |
| Function | Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter. Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain. Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency. May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow. May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine. Mediates the bidirectional transport of polyamine agmatine. Also transports guanidine. May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling. |
| Protein Name | Solute Carrier Family 22 Member 3Extraneuronal Monoamine TransporterEmtOrganic Cation Transporter 3Oct3 |
| Database Links | Reactome: R-HSA-2161517Reactome: R-HSA-549127 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasolateral Cell MembraneMitochondrion MembraneEndomembrane SystemNucleus MembraneNucleus Outer MembraneLocalized To The Apical/Brush Border Membrane Of EnterocytesLocalized To The Luminal/Apical Membrane Of Ciliated Epithelial Cells In BronchiLocalized To The Basolateral Membrane Of Intermediate Cells In BronchiLocalized To The Entire Plasma Membrane Of Basal Cells In Bronchi |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 3 antibodyAnti-Extraneuronal Monoamine Transporter antibodyAnti-Emt antibodyAnti-Organic Cation Transporter 3 antibodyAnti-Oct3 antibodyAnti-SLC22A3 antibodyAnti-EMTH antibodyAnti-OCT3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
