| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SLC1A2 (550-574) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.54 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | SLC1A2 |
| Gene ID: | 6506 |
| Uniprot ID: | EAA2_HUMAN |
| Immunogen Region: | 550-574 |
| Specificity: | Will not cross react with EAAT1 protein. |
| Immunogen: | Synthetic peptide corresponding to C terminal amino acids 550-574 of Human EAAT2. |
| Post Translational Modifications | Glycosylated. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. |
| Protein Name | Excitatory Amino Acid Transporter 2 Glutamate/Aspartate Transporter Ii Sodium-Dependent Glutamate/Aspartate Transporter 2 Solute Carrier Family 1 Member 2 |
| Database Links | Reactome: R-HSA-210455 Reactome: R-HSA-210500 Reactome: R-HSA-425393 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 2 antibody Anti-Glutamate/Aspartate Transporter Ii antibody Anti-Sodium-Dependent Glutamate/Aspartate Transporter 2 antibody Anti-Solute Carrier Family 1 Member 2 antibody Anti-SLC1A2 antibody Anti-EAAT2 antibody Anti-GLT1 antibody |
Information sourced from Uniprot.org