| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SLC15A2 |
| Gene ID: |
6565 |
| Uniprot ID: |
S15A2_HUMAN |
| Immunogen Region: |
450-550 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 450-550 of human SLC15A2 (NP_001139470.1). |
| Immunogen Sequence: |
VQEKNWYSLVIREDGNSISS MMVKDTESRTTNGMTTVRFV NTLHKDVNISLSTDTSLNVG EDYGVSAYRTVQRGEYPAVH CRTEDKNFSLNLGLLDFGAA Y |
| Tissue Specificity | Expressed in kidney. Not detected in intestine. Highly expressed in macrophages. |
| Function | Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1. In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate. Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs. Transports the dipeptide-like aminopeptidase inhibitor bestatin. Also able to transport carnosine. Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand. |
| Protein Name | Solute Carrier Family 15 Member 2Kidney H(+/Peptide CotransporterOligopeptide Transporter - Kidney IsoformPeptide Transporter 2 |
| Database Links | Reactome: R-HSA-427975 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesiclePhagosome MembraneCell MembraneAssociated With The Cell Membrane In Resting Macrophages And Enriched In Phagocytic Cups And Phagosomes After Particle Internalization |
| Alternative Antibody Names | Anti-Solute Carrier Family 15 Member 2 antibodyAnti-Kidney H(+/Peptide Cotransporter antibodyAnti-Oligopeptide Transporter - Kidney Isoform antibodyAnti-Peptide Transporter 2 antibodyAnti-SLC15A2 antibodyAnti-PEPT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
