| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Solute carrier family 12 member 5 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC12A5 |
| Gene ID: | 57468 |
| Uniprot ID: | S12A5_HUMAN |
| Specificity: | This antibody detects endogenous levels of KCC2/SLC12A5 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human KCC2/SLC12A5 |
| Post Translational Modifications | Phosphorylated at Thr-929 and Thr-1030 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), inhibiting the potassium-chloride cotransport activity. |
| Function | Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation. |
| Protein Name | Solute Carrier Family 12 Member 5 Electroneutral Potassium-Chloride Cotransporter 2 K-Cl Cotransporter 2 Hkcc2 Neuronal K-Cl Cotransporter |
| Database Links | Reactome: R-HSA-426117 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendrite Detected On Dendrites But Not On Axons Of Spinal Cord Neurons And At Gphn-Positive Inhibitory Synapses |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 5 antibody Anti-Electroneutral Potassium-Chloride Cotransporter 2 antibody Anti-K-Cl Cotransporter 2 antibody Anti-Hkcc2 antibody Anti-Neuronal K-Cl Cotransporter antibody Anti-SLC12A5 antibody Anti-KCC2 antibody Anti-KIAA1176 antibody |
Information sourced from Uniprot.org