Anti-SLC12A1 antibody (1-177 aa) (STJ11107416)

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STJ11107416
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: SLC12A1
Gene ID: 6557
Uniprot ID: S12A1_HUMAN
Immunogen Region: 1-177 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human SLC12A1 (NP_000329.2).
Immunogen Sequence: MSLNNSSNVFLDSVPSNTNR FQVSVINENHESSAAADDNT DPPHYEETSFGDEAQKRLRI SFRPGNQECYDNFLQSGETA KTDASFHAYDSHTNTYYLQT FGHNTMDAVPKIEYYRNTGS ISGPKVNRPSLLEIHEQLAK NVAVTPSSADRVANGDGIPG DEQAENKEDDQAGVVKF
Tissue Specificity Kidney.localizes to the thick ascending limbs (at protein level).
Post Translational Modifications Phosphorylated at Ser-91, Thr-100 and Thr-105 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), promoting its activity.
Function Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system.
Protein Name Solute Carrier Family 12 Member 1
Bumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 1
Bsc1
Kidney-Specific Na-K-Cl Symporter
Na-K-2cl Cotransporter 2
Nkcc2
Database Links Reactome: R-HSA-426117
Reactome: R-HSA-5619104
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Solute Carrier Family 12 Member 1 antibody
Anti-Bumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 1 antibody
Anti-Bsc1 antibody
Anti-Kidney-Specific Na-K-Cl Symporter antibody
Anti-Na-K-2cl Cotransporter 2 antibody
Anti-Nkcc2 antibody
Anti-SLC12A1 antibody
Anti-NKCC2 antibody

Information sourced from Uniprot.org

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