| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC11A2 |
| Gene ID: | 4891 |
| Uniprot ID: | NRAM2_HUMAN |
| Immunogen Region: | 1-63 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human DMT1/SLC11A2 (NP_001167597.1). |
| Immunogen Sequence: | MVLGPEQKMSDDSVSGDHGE SASLGNINPAYSNPSLSQSP GDSEEYFATYFNEKISIPEE EYS |
| Tissue Specificity | Ubiquitously expressed. Expressed in erythroid progenitors. |
| Post Translational Modifications | Ubiquitinated by WWP2. N-glycosylated. |
| Function | Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells. Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense. Can mediate uncoupled fluxes of either protons or metal ions. |
| Protein Name | Natural Resistance-Associated Macrophage Protein 2 Nramp 2 Divalent Cation Transporter 1 Divalent Metal Transporter 1 Dmt-1 Solute Carrier Family 11 Member 2 |
| Database Links | Reactome: R-HSA-425410 Reactome: R-HSA-5619048 Reactome: R-HSA-917937 |
| Cellular Localisation | Isoform 1: Early Endosome Membrane Multi-Pass Membrane Protein Apical Cell Membrane Predominantly Localizes In Early Endosomes That Underlie The Apical Membrane Of Polarized Epithelia Isoform 2: Late Endosome Membrane Lysosome Membrane Cell Membrane Extracellular Vesicle Membrane Isoform 3: Cell Membrane Mitochondrion Outer Membrane Golgi Apparatus Trans-Golgi Network Membrane Recycling Endosome Membrane |
| Alternative Antibody Names | Anti-Natural Resistance-Associated Macrophage Protein 2 antibody Anti-Nramp 2 antibody Anti-Divalent Cation Transporter 1 antibody Anti-Divalent Metal Transporter 1 antibody Anti-Dmt-1 antibody Anti-Solute Carrier Family 11 Member 2 antibody Anti-SLC11A2 antibody Anti-DCT1 antibody Anti-DMT1 antibody Anti-NRAMP2 antibody Anti-OK antibody Anti-SW-cl.20 antibody |
Information sourced from Uniprot.org