| Tissue Specificity | Ubiquitously expressed. Expressed in erythroid progenitors. |
| Post Translational Modifications | Ubiquitinated by WWP2. N-glycosylated. |
| Function | Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells. Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense. Can mediate uncoupled fluxes of either protons or metal ions. |
| Protein Name | Natural Resistance-Associated Macrophage Protein 2Nramp 2Divalent Cation Transporter 1Divalent Metal Transporter 1Dmt-1Solute Carrier Family 11 Member 2 |
| Database Links | Reactome: R-HSA-425410Reactome: R-HSA-5619048Reactome: R-HSA-917937 |
| Cellular Localisation | Isoform 1: Early Endosome MembraneMulti-Pass Membrane ProteinApical Cell MembranePredominantly Localizes In Early Endosomes That Underlie The Apical Membrane Of Polarized EpitheliaIsoform 2: Late Endosome MembraneLysosome MembraneCell MembraneExtracellular Vesicle MembraneIsoform 3: Cell MembraneMitochondrion Outer MembraneGolgi ApparatusTrans-Golgi Network MembraneRecycling Endosome Membrane |
| Alternative Antibody Names | Anti-Natural Resistance-Associated Macrophage Protein 2 antibodyAnti-Nramp 2 antibodyAnti-Divalent Cation Transporter 1 antibodyAnti-Divalent Metal Transporter 1 antibodyAnti-Dmt-1 antibodyAnti-Solute Carrier Family 11 Member 2 antibodyAnti-SLC11A2 antibodyAnti-DCT1 antibodyAnti-DMT1 antibodyAnti-NRAMP2 antibodyAnti-OK antibodyAnti-SW-cl.20 antibody |
Information sourced from Uniprot.org
