| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DMT1 (1-63) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC11A2 |
| Gene ID: |
4891 |
| Uniprot ID: |
NRAM2_HUMAN |
| Immunogen Region: |
1-63 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human DMT1/SLC11A2 (NP_001167597.1). |
| Immunogen Sequence: |
MVLGPEQKMSDDSVSGDHGE SASLGNINPAYSNPSLSQSP GDSEEYFATYFNEKISIPEE EYS |
| Tissue Specificity | Ubiquitously expressed. Expressed in erythroid progenitors. |
| Post Translational Modifications | Ubiquitinated by WWP2. N-glycosylated. |
| Function | Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells. Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense. Can mediate uncoupled fluxes of either protons or metal ions. |
| Protein Name | Natural Resistance-Associated Macrophage Protein 2Nramp 2Divalent Cation Transporter 1Divalent Metal Transporter 1Dmt-1Solute Carrier Family 11 Member 2 |
| Database Links | Reactome: R-HSA-425410Reactome: R-HSA-5619048Reactome: R-HSA-917937 |
| Cellular Localisation | Isoform 1: Early Endosome MembraneMulti-Pass Membrane ProteinApical Cell MembranePredominantly Localizes In Early Endosomes That Underlie The Apical Membrane Of Polarized EpitheliaIsoform 2: Late Endosome MembraneLysosome MembraneCell MembraneExtracellular Vesicle MembraneIsoform 3: Cell MembraneMitochondrion Outer MembraneGolgi ApparatusTrans-Golgi Network MembraneRecycling Endosome Membrane |
| Alternative Antibody Names | Anti-Natural Resistance-Associated Macrophage Protein 2 antibodyAnti-Nramp 2 antibodyAnti-Divalent Cation Transporter 1 antibodyAnti-Divalent Metal Transporter 1 antibodyAnti-Dmt-1 antibodyAnti-Solute Carrier Family 11 Member 2 antibodyAnti-SLC11A2 antibodyAnti-DCT1 antibodyAnti-DMT1 antibodyAnti-NRAMP2 antibodyAnti-OK antibodyAnti-SW-cl.20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
